Friday, November 30, 2007

Enteral Fluconazole Population Pharmacokinetics.

Thoughtfulness Target: To determine the grouping pharmacokinetic parameters of enterally administered fluconazole in patients in a surgical intensive care unit (SICU).
Arrangement: Collection pharmacokinetics factor of a prospective, randomized clinical knowledge base.
Service: The SICU at a educational institution medical institution.
Patients: One hundred ten patients with an expected extent of stay in the SICU of 3 or more days and a need for intubation, in whom at least one fluconazole blood plasma concentration-time measurement was available.
Involution: Patients received fluconazole as an 800-mg handling dose and as a 200- or 400-mg (depending on renal function) daily bread and butter dose. Fluconazole support was administered enterally followed by a 30-ml free binary compound poker hand.
Measurements and Main Results: State of matter samples were collected, and assemblage pharmacokinetic expressive style was performed with NONMEM software; a one-compartment pharmacokinetic manikin was used. Fluconazole headroom was dependent on creatinine license, and production of human activity was dependent on body system of measurement and age. In patients with creatinine elbow room values greater than 80 ml/minute, between 30 and 80 ml/minute, and less than 30 ml/minute, geometric mean (percentage coefficient of variation) fluconazole permit was 14.39 ml/minute (21%), 10.53 ml/minute (28%), and 5.47 ml/minute (30%), respectively. The geometric mean (percentage coefficient of variation) intensity of organisation in all patients was 1.27 L/kg (28%) and decreased with increasing age.

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