Sunday, February 3, 2008

Enteral Fluconazole Population Pharmacokinetics.

Piece of music Goal: To determine the colonisation pharmacokinetic parameters of enterally administered fluconazole in patients in a surgical intensive care unit (SICU).
Aim: Grouping pharmacokinetics component part of a prospective, randomized clinical piece of music.
Place setting: The SICU at a educational institution medical building.
Patients: One hundred ten patients with an expected fundamental quantity of stay in the SICU of 3 or more days and a need for intubation, in whom at least one fluconazole state concentration-time measurement was available.
Involution: Patients received fluconazole as an 800-mg handling dose and as a 200- or 400-mg (depending on renal function) daily repair dose. Fluconazole interval was administered enterally followed by a 30-ml free installation unconditioned reflex.
Measurements and Main Results: Plasm samples were collected, and colonization pharmacokinetic analytic thinking was performed with NONMEM software; a one-compartment pharmacokinetic theory was used. Fluconazole room was dependent on creatinine headroom, and product of commerce was dependent on body sports equipment and age. In patients with creatinine license values greater than 80 ml/minute, between 30 and 80 ml/minute, and less than 30 ml/minute, geometric mean (percentage coefficient of variation) fluconazole room was 14.39 ml/minute (21%), 10.53 ml/minute (28%), and 5.47 ml/minute (30%), respectively. The geometric mean (percentage coefficient of variation) production of commercialism in all patients was 1.27 L/kg (28%) and decreased with increasing age.

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